InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANKRD13B

Summary

InnateDB Protein

IDBP-600722.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANKRD13B

Protein Name

ankyrin repeat domain 13B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000431958

InnateDB Gene

IDBG-38520 (ANKRD13B)

Protein Structure

UniProt Annotation

Function

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269PubMed:22298428}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22298428}. Late endosome {ECO:0000269PubMed:22298428}. Early endosome {ECO:0000269PubMed:22298428}. Note=Interaction with EGFR may enhance association with the cell membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005769	early endosome
GO:0005770	late endosome
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR003903 Ubiquitin interacting motif
IPR020683 Ankyrin repeat-containing domain
IPR021832 Ankyrin repeat domain-containing protein 13

PFAM

PF00023
PF13606
PF02809
PF11929
PF12796
PF11904

PRINTS

PR01415

PIRSF

SMART

SM00248
SM00726

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt