Version 5.4
Homo sapiens Protein: GABRB3
Summary
InnateDB Protein IDBP-600728.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRB3
Protein Name gamma-aminobutyric acid (GABA) A receptor, beta 3
Synonyms ECA5;
Species Homo sapiens
Ensembl Protein ENSP00000439169
InnateDB Gene IDBG-4360 (GABRB3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
GO:0022851 GABA-gated chloride ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:0060021 palate development
GO:0071420 cellular response to histamine
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
GO:1902711 GABA-A receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR002289 Gamma-aminobutyric-acid A receptor, beta subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
PFAM PF02932
PF02931
PRINTS PR01160
PR00253
PR00252
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28472
PhosphoSite PhosphoSite-P28472
TrEMBL G3V5B4
UniProt Splice Variant
Entrez Gene 2562
UniGene Hs.727263
RefSeq NP_001178249
HUGO HGNC:4083
OMIM 137192
CCDS CCDS53920
HPRD 08844
IMGT
EMBL AC009878 AC011196 AC104569 AC127511 AC135999 AC145167 AC145196 AK295167 AK302822 BC010641 CH471151 EU606048 L04311 M82919
GenPept AAA52507 AAA52508 AAA52511 AAH10641 BAH11997 BAH13811 EAW57655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca