Version 5.4
Homo sapiens Protein: EIF1AD
Summary
InnateDB Protein IDBP-600763.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF1AD
Protein Name eukaryotic translation initiation factor 1A domain containing
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000435439
InnateDB Gene IDBG-58200 (EIF1AD)
Protein Structure
UniProt Annotation
Function Plays a role into cellular response to oxidative stress. Decreases cell proliferation. {ECO:0000269PubMed:20644585, ECO:0000269PubMed:22095125}.
Subcellular Localization Nucleus {ECO:0000269PubMed:20644585, ECO:0000269PubMed:22095125}.
Disease Associations
Tissue Specificity Expressed in the glioblastoma cell line U- 87MG, the embryonic kidney cell line HEK293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF-7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562. {ECO:0000269PubMed:20644585}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005634 nucleus
GO:0043231 intracellular membrane-bounded organelle
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001253 Translation initiation factor 1A (eIF-1A)
IPR006196 RNA-binding domain, S1, IF1 type
IPR012340 Nucleic acid-binding, OB-fold
PFAM PF01176
PRINTS
PIRSF
SMART SM00652
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N9N8
PhosphoSite PhosphoSite-Q8N9N8
TrEMBL E9PS76
UniProt Splice Variant
Entrez Gene 84285
UniGene Hs.425178
RefSeq
HUGO HGNC:28147
OMIM
CCDS CCDS8124
HPRD 14411
IMGT
EMBL AK094129 AK311891 AP006287 BC005131 CH471076
GenPept AAH05131 BAC04293 BAG34832 EAW74478 EAW74479 EAW74480 EAW74481 EAW74482

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca