InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU6F1

Summary

InnateDB Protein

IDBP-600936.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU6F1

Protein Name

POU class 6 homeobox 1

Synonyms

BRN5; MPOU; TCFB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000448389

InnateDB Gene

IDBG-33183 (POU6F1)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0007507	heart development
GO:0007517	muscle organ development