InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2R5A

Summary

InnateDB Protein

IDBP-601126.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2R5A

Protein Name

protein phosphatase 2, regulatory subunit B', alpha

Synonyms

B56A; PR61A;

Species

Homo sapiens

Ensembl Protein

ENSP00000442866

InnateDB Gene

IDBG-106540 (PPP2R5A)

Protein Structure

UniProt Annotation

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subcellular Localization

Cytoplasm. Nucleus. Chromosome, centromere. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.

Disease Associations

Tissue Specificity

Widely expressed with the highest expression in heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0019900	kinase binding

Biological Process

GO:0007165	signal transduction
GO:0035307	positive regulation of protein dephosphorylation
GO:0090005	negative regulation of establishment of protein localization to plasma membrane
GO:0090219	negative regulation of lipid kinase activity

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031430	M band