Version 5.4
Homo sapiens Protein: CMIP
Summary
InnateDB Protein IDBP-601149.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CMIP
Protein Name c-Maf inducing protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000440401
InnateDB Gene IDBG-43672 (CMIP)
Protein Structure
UniProt Annotation
Function Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269PubMed:12939343, ECO:0000269PubMed:15128042}.
Subcellular Localization Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients.
Disease Associations
Tissue Specificity Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver. {ECO:0000269PubMed:12939343}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IY22
PhosphoSite PhosphoSite-Q8IY22
TrEMBL
UniProt Splice Variant
Entrez Gene 80790
UniGene Hs.743668
RefSeq NP_085132
HUGO HGNC:24319
OMIM 610112
CCDS CCDS54045
HPRD 10839
IMGT
EMBL AB051481 AC092135 AC092139 AC099480 AC099524 AY172689 BC038113
GenPept AAH38113 AAO17720 BAB21785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca