Version 5.4
Homo sapiens Protein: MREG
Summary
InnateDB Protein IDBP-60126.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MREG
Protein Name melanoregulin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263268
InnateDB Gene IDBG-80558 (MREG)
Protein Structure
UniProt Annotation
Function Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). {ECO:0000250}.
Subcellular Localization Apical cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes to the inner segment and basal outer segment of rods in the retina. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in photoreceptor cells (at protein level). {ECO:0000269PubMed:17260955}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0016324 apical plasma membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N565
PhosphoSite PhosphoSite-Q8N565
TrEMBL C9JYV9
UniProt Splice Variant
Entrez Gene 55686
UniGene Hs.728617
RefSeq
HUGO HGNC:25478
OMIM 609207
CCDS CCDS46513
HPRD 07645
IMGT
EMBL AC010686 AC093382 AF068290 AK000978 BC032747 BC082990
GenPept AAF65179 AAH32747 AAH82990 AAY14656 AAY14719 BAA91453

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca