InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DBN1

Summary

InnateDB Protein

IDBP-60133.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DBN1

Protein Name

drebrin 1

Synonyms

D0S117E;

Species

Homo sapiens

Ensembl Protein

ENSP00000292385

InnateDB Gene

IDBG-60129 (DBN1)

Protein Structure

UniProt Annotation

Function

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. {ECO:0000269PubMed:20215400}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20215400}. Cytoplasm, cell cortex {ECO:0000269PubMed:20215400}. Cell junction {ECO:0000269PubMed:20215400}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC).

Disease Associations

Tissue Specificity

Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level). {ECO:0000269PubMed:20215400}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	86 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding

Biological Process

GO:0007015	actin filament organization
GO:0007399	nervous system development
GO:0010643	cell communication by chemical coupling
GO:0010644	cell communication by electrical coupling
GO:0032507	maintenance of protein location in cell
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048699	generation of neurons
GO:0050773	regulation of dendrite development
GO:0061351	neural precursor cell proliferation

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005921	gap junction
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030425	dendrite
GO:0042641	actomyosin