Version 5.4
Homo sapiens Protein: SAA2
Summary
InnateDB Protein IDBP-601380.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAA2
Protein Name serum amyloid A2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000436126
InnateDB Gene IDBG-34632 (SAA2)
Protein Structure
UniProt Annotation
Function Major acute phase reactant. Apolipoprotein of the HDL complex.
Subcellular Localization Secreted.
Disease Associations Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA2 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. {ECO:0000269PubMed:1463770}.
Tissue Specificity Expressed by the liver; secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006953 acute-phase response
Cellular Component
GO:0005576 extracellular region
GO:0034364 high-density lipoprotein particle
Protein Structure and Domains
PDB ID
InterPro IPR000096 Serum amyloid A protein
PFAM PF00277
PRINTS PR00306
PIRSF PIRSF002472
SMART SM00197
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0DJI9
PhosphoSite PhosphoSite-P0DJI9
TrEMBL
UniProt Splice Variant
Entrez Gene 6289
UniGene Hs.731376
RefSeq
HUGO HGNC:10514
OMIM 104751
CCDS CCDS7833
HPRD 00098
IMGT
EMBL AC090099 AK307163 BC020795 CH471064 J03474 M23699 M23700 M26152 X51440 X51444 X51445 X56653
GenPept AAA64800 AAA64801 AAA85338 AAB59539 AAH20795 CAA35805 CAA35809 CAA35810 CAA39975 EAW68414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca