Version 5.4
Homo sapiens Protein: CLEC2D
Summary
InnateDB Protein IDBP-601524.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC2D
Protein Name C-type lectin domain family 2, member D
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000437861
InnateDB Gene IDBG-17917 (CLEC2D)
Protein Structure
UniProt Annotation
Function Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans. {ECO:0000269PubMed:14753741, ECO:0000269PubMed:15104121, ECO:0000269PubMed:16339513}.
Subcellular Localization Cell membrane; Single-pass type II membrane protein. Cell surface.Isoform 2: Endoplasmic reticulum.Isoform 4: Endoplasmic reticulum.
Disease Associations
Tissue Specificity Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells. {ECO:0000269PubMed:10541800, ECO:0000269PubMed:20843815}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0030246 carbohydrate binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR016187 C-type lectin fold
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHP7
PhosphoSite PhosphoSite-Q9UHP7
TrEMBL
UniProt Splice Variant
Entrez Gene 29121
UniGene
RefSeq
HUGO HGNC:14351
OMIM 605659
CCDS
HPRD 16134
IMGT
EMBL AC007068 AC010186 AF133299 AF285087 AF285088 AF285089 AY144606 BC019883 CH471094 FN813349 FN813350 FN813351
GenPept AAF22159 AAG00514 AAG00515 AAG00516 AAH19883 AAN59996 CBL81070 CBL81071 CBL81072 EAW96114

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca