InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTR4

Summary

InnateDB Protein

IDBP-601536.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR4

Protein Name

5-hydroxytryptamine (serotonin) receptor 4

Synonyms

5-HT4; 5-HT4R;

Species

Homo sapiens

Ensembl Protein

ENSP00000435904

InnateDB Gene

IDBG-52561 (HTR4)

Protein Structure

UniProt Annotation

Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. {ECO:0000269PubMed:15118808}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007210	serotonin receptor signaling pathway
GO:0007268	synaptic transmission
GO:0008284	positive regulation of cell proliferation
GO:0032098	regulation of appetite

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane