Version 5.4
Homo sapiens Protein: DEFA6
Summary
InnateDB Protein IDBP-6016.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEFA6
Protein Name defensin, alpha 6, Paneth cell-specific
Synonyms DEF6; HD-6;
Species Homo sapiens
Ensembl Protein ENSP00000297436
InnateDB Gene IDBG-6012 (DEFA6)
Protein Structure
UniProt Annotation
Function Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1. {ECO:0000269PubMed:15616305, ECO:0000269PubMed:17088326}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Paneth cells of the small intestine.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006952 defense response
GO:0019731 antibacterial humoral response
GO:0031640 killing of cells of other organism
GO:0045087 innate immune response (InnateDB)
GO:0050832 defense response to fungus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
Protein Structure and Domains
PDB ID
InterPro IPR002366 Defensin propeptide
IPR006080 Beta defensin/Neutrophil defensin
IPR006081 Mammalian defensins
IPR016327 Alpha-defensin
PFAM PF00879
PF00323
PRINTS
PIRSF PIRSF001875
SMART SM00048
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q01524
PhosphoSite PhosphoSite-Q01524
TrEMBL
UniProt Splice Variant
Entrez Gene 1671
UniGene Hs.711
RefSeq NP_001917
HUGO HGNC:2765
OMIM 600471
CCDS CCDS5960
HPRD 02719
IMGT
EMBL AF200455 BC069667 BC069710 BC069728 BC069769 BC093951 BC093953 CH471153 M98331 U33317
GenPept AAB59357 AAC50382 AAH69667 AAH69710 AAH69728 AAH69769 AAH93951 AAH93953 AAT68876 EAW80484

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca