InnateDB Protein
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IDBP-60171.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLSCR1
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Protein Name
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phospholipid scramblase 1
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Synonyms
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MMTRA1B;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000345494
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InnateDB Gene
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IDBG-60169 (PLSCR1)
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Protein Structure
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Function |
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
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Subcellular Localization |
Cell membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
107
[view]
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Protein-Protein |
103
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0005154
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epidermal growth factor receptor binding
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GO:0005509
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calcium ion binding
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GO:0005515
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protein binding
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GO:0017124
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SH3 domain binding
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GO:0017128
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phospholipid scramblase activity
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GO:0019899
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enzyme binding
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GO:0042609
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CD4 receptor binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005552
Scramblase
IPR025659
Tubby C-terminal-like domain
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PFAM |
PF03803
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O15162
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PhosphoSite |
PhosphoSite-O15162
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TrEMBL |
C9JSI9
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UniProt Splice Variant |
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Entrez Gene |
5359
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UniGene |
Hs.595419
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RefSeq |
NP_066928
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HUGO |
HGNC:9092
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OMIM |
604170
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CCDS |
CCDS3135
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HPRD |
08855
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IMGT |
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EMBL |
AB006746
AC069528
AC116544
AF098642
AF224492
AK300181
AK313377
BC021100
BC032718
CH471052
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GenPept |
AAC99413
AAF80593
AAH21100
AAH32718
BAA32568
BAG36175
BAG61960
EAW78926
EAW78929
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