InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OTUB2

Summary

InnateDB Protein

IDBP-601876.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OTUB2

Protein Name

OTU domain, ubiquitin aldehyde binding 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000451283

InnateDB Gene

IDBG-17807 (OTUB2)

Protein Structure

UniProt Annotation

Function

Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'- linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. {ECO:0000269PubMed:12704427, ECO:0000269PubMed:18954305, ECO:0000269PubMed:23827681}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Expressed at higher level in brain. {ECO:0000269PubMed:12704427}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0008242	omega peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006520	cellular amino acid metabolic process
GO:0016579	protein deubiquitination
GO:0035871	protein K11-linked deubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination