Version 5.4
Homo sapiens Protein: SERPINA4
Summary
InnateDB Protein IDBP-601978.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA4
Protein Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
Synonyms KAL; kallistatin; KLST; KST; PI-4; PI4;
Species Homo sapiens
Ensembl Protein ENSP00000451172
InnateDB Gene IDBG-18320 (SERPINA4)
Protein Structure
UniProt Annotation
Function Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. {ECO:0000269PubMed:8227002}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed by the liver and secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P29622
PhosphoSite PhosphoSite-P29622
TrEMBL A0A024R6I9
UniProt Splice Variant
Entrez Gene 5267
UniGene Hs.719893
RefSeq NP_001275961
HUGO HGNC:8948
OMIM 147935
CCDS CCDS9927
HPRD 01004
IMGT
EMBL BC014992 BX248009 BX248760 CH471061 L19684 L28101
GenPept AAA59454 AAC41706 AAH14992 CAD62337 CAD66567 EAW81579 EAW81580 EAW81581

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca