InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP6

Summary

InnateDB Protein

IDBP-602053.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP6

Protein Name

A kinase (PRKA) anchor protein 6

Synonyms

ADAP100; ADAP6; AKAP100; mAKAP; PRKA6;

Species

Homo sapiens

Ensembl Protein

ENSP00000450531

InnateDB Gene

IDBG-4482 (AKAP6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0032947	protein complex scaffold
GO:0034237	protein kinase A regulatory subunit binding
GO:0043495	protein anchor
GO:0044325	ion channel binding
GO:0051018	protein kinase A binding

Biological Process

GO:0001508	action potential
GO:0006605	protein targeting
GO:0010738	regulation of protein kinase A signaling
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019933	cAMP-mediated signaling
GO:0030307	positive regulation of cell growth
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032514	positive regulation of protein phosphatase type 2B activity
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051533	positive regulation of NFAT protein import into nucleus
GO:0060306	regulation of membrane repolarization
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development
GO:0070886	positive regulation of calcineurin-NFAT signaling cascade
GO:0071320	cellular response to cAMP
GO:0071345	cellular response to cytokine stimulus
GO:1901381	positive regulation of potassium ion transmembrane transport
GO:1902261	positive regulation of delayed rectifier potassium channel activity

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005901	caveola
GO:0014701	junctional sarcoplasmic reticulum membrane
GO:0014704	intercalated disc
GO:0016529	sarcoplasmic reticulum
GO:0030315	T-tubule
GO:0031965	nuclear membrane
GO:0034704	calcium channel complex
GO:0048471	perinuclear region of cytoplasm