Version 5.4
Homo sapiens Protein: SOS2
Summary
InnateDB Protein IDBP-602058.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOS2
Protein Name son of sevenless homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000445328
InnateDB Gene IDBG-5912 (SOS2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001849 Pleckstrin homology domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR007125 Histone core
IPR009072 Histone-fold
IPR023578 Ras guanine nucleotide exchange factor domain
PFAM PF00621
PF00618
PF00169
PF00617
PF00125
PRINTS
PIRSF
SMART SM00325
SM00229
SM00233
SM00147
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q07890
PhosphoSite PhosphoSite-Q07890
TrEMBL B4DJ05
UniProt Splice Variant
Entrez Gene 6655
UniGene Hs.732397
RefSeq
HUGO HGNC:11188
OMIM 601247
CCDS
HPRD 03149
IMGT
EMBL AK295868 AL109758 BC117261 BC143367 CH471078 L13858 L20686
GenPept AAA35914 AAA91852 AAI17262 AAI43368 BAG58667 EAW65727 EAW65728

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca