Version 5.4
Homo sapiens Protein: ME3
Summary
InnateDB Protein IDBP-602299.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ME3
Protein Name malic enzyme 3, NADP(+)-dependent, mitochondrial
Synonyms NADP-ME;
Species Homo sapiens
Ensembl Protein ENSP00000431182
InnateDB Gene IDBG-66961 (ME3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006108 malate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001891 Malic oxidoreductase
IPR012301 Malic enzyme, N-terminal domain
IPR012302 Malic enzyme, NAD-binding
PFAM PF00390
PF03949
PRINTS PR00072
PIRSF PIRSF000106
SMART SM00919
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PNN2
UniProt Splice Variant
Entrez Gene 10873
UniGene Hs.199743
RefSeq XP_006718486
HUGO HGNC:6985
OMIM 604626
CCDS
HPRD 06862
IMGT
EMBL AP001148 AP001831 AP002492
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca