InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PACSIN1

Summary

InnateDB Protein

IDBP-602330.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PACSIN1

Protein Name

protein kinase C and casein kinase substrate in neurons 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000439639

InnateDB Gene

IDBG-83573 (PACSIN1)

Protein Structure

UniProt Annotation

Function

Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269PubMed:19549836, ECO:0000269PubMed:22573331, ECO:0000269PubMed:23236520}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain and, at much lower levels, in heart and pancreas. {ECO:0000269PubMed:11179684}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0007015	actin filament organization
GO:0045087	innate immune response (InnateDB)
GO:0048488	synaptic vesicle endocytosis
GO:0048666	neuron development
GO:0048812	neuron projection morphogenesis
GO:0072657	protein localization to membrane
GO:0090002	establishment of protein localization to plasma membrane
GO:0097320	membrane tubulation
GO:1900006	positive regulation of dendrite development

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0030659	cytoplasmic vesicle membrane
GO:0032587	ruffle membrane
GO:0043679	axon terminus
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm