InnateDB Protein
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IDBP-602402.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TCL1A
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Protein Name
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T-cell leukemia/lymphoma 1A
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Synonyms
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TCL1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000450496
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InnateDB Gene
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IDBG-18937 (TCL1A)
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Protein Structure
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Function |
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. {ECO:0000269PubMed:10716693, ECO:0000269PubMed:10983986, ECO:0000269PubMed:11707444, ECO:0000269PubMed:11839817}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000269PubMed:7987816}. Endoplasmic reticulum {ECO:0000269PubMed:7987816}. Note=Microsomal fraction.
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Disease Associations |
Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
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Tissue Specificity |
Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004832
TCL1/MTCP1
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PFAM |
PF01840
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P56279
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PhosphoSite |
PhosphoSite-P56279
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TrEMBL |
A0A024R6G5
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UniProt Splice Variant |
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Entrez Gene |
8115
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UniGene |
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RefSeq |
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HUGO |
HGNC:11648
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OMIM |
186960
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CCDS |
CCDS9941
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HPRD |
01744
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IMGT |
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EMBL |
BC003574
BC005831
BC014024
CH471061
CR456796
X82240
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GenPept |
AAH03574
AAH05831
AAH14024
CAA57708
CAG33077
EAW81622
EAW81623
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