Version 5.4
Homo sapiens Protein: MARVELD1
Summary
InnateDB Protein IDBP-602427.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARVELD1
Protein Name MARVEL domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000441365
InnateDB Gene IDBG-85685 (MARVELD1)
Protein Structure
UniProt Annotation
Function Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000269PubMed:19364627}. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed in normal tissues. Down- regulated in multiple primary tumors. {ECO:0000269PubMed:19364627}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR008253 Marvel domain
PFAM PF01284
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BSK0
PhosphoSite PhosphoSite-Q9BSK0
TrEMBL
UniProt Splice Variant
Entrez Gene 83742
UniGene Hs.741625
RefSeq NP_113672
HUGO HGNC:28674
OMIM
CCDS
HPRD 14364
IMGT
EMBL AL355315 BC004995 BC062544
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca