Version 5.4
Homo sapiens Protein: RBFOX1
Summary
InnateDB Protein IDBP-602537.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBFOX1
Protein Name RNA binding protein, fox-1 homolog (C. elegans) 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000447753
InnateDB Gene IDBG-13650 (RBFOX1)
Protein Structure
UniProt Annotation
Function RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. {ECO:0000269PubMed:16537540}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in muscle and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
GO:0050658 RNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR017325 RNA binding protein Fox-1
IPR025670 Fox-1 C-terminal domain
PFAM PF00076
PF12414
PRINTS
PIRSF PIRSF037932
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NWB1
PhosphoSite PhosphoSite-Q9NWB1
TrEMBL
UniProt Splice Variant
Entrez Gene 54715
UniGene Hs.617542
RefSeq NP_001135805
HUGO HGNC:18222
OMIM 605104
CCDS CCDS55984
HPRD 16091
IMGT
EMBL AC005774 AC006075 AC006112 AC007012 AC007217 AC007222 AC007223 AC009135 AC022206 AC023829 AC027683 AC079410 AC125796 AC131390 AF094849 AF107203 AF109106 AF109107 AF109108 AF109109 AF109110 AF109111 AF109112 AF109113 AF109114 AF109115 AF109116 AF109117 AF109118 AF109119 AF109120 AF229057 AF448859 AK001027 BC113691
GenPept AAF78291 AAI13692 AAL71904 AAL83405 AAL83406 AAL83407 AAL83408 AAL83409 AAP41925 BAA91472

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca