Version 5.4
Homo sapiens Protein: PEAK1
Summary
InnateDB Protein IDBP-602552.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEAK1
Protein Name Pseudopodium-enriched atypical kinase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000452796
InnateDB Gene IDBG-24254 (PEAK1)
Protein Structure
UniProt Annotation
Function Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN. {ECO:0000269PubMed:20534451}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:20534451}. Cell junction, focal adhesion {ECO:0000269PubMed:20534451}. Note=Colocalizes with F-actin in serum-rich medium. Actin colocalization is reduced during serum starvation.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0034446 substrate adhesion-dependent cell spreading
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H792
PhosphoSite PhosphoSite-Q9H792
TrEMBL H3BUZ5
UniProt Splice Variant
Entrez Gene 79834
UniGene Hs.9587
RefSeq XP_005254727
HUGO HGNC:29431
OMIM 614248
CCDS CCDS42062
HPRD
IMGT
EMBL AB082533 AC060773 AC087465 AC090984 AC107883 AK024793 AK074157 AK091802 AK127658
GenPept BAB15006 BAB84983 BAC02711 BAC87076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca