InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CST4

Summary

InnateDB Protein

IDBP-60261.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CST4

Protein Name

cystatin S

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000217423

InnateDB Gene

IDBG-60259 (CST4)

Protein Structure

UniProt Annotation

Function

This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.

Subcellular Localization

Secreted {ECO:0000269PubMed:20189825}.

Disease Associations

Tissue Specificity

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269PubMed:20189825}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0001895	retina homeostasis
GO:0010951	negative regulation of endopeptidase activity
GO:0045861	negative regulation of proteolysis