Homo sapiens Protein: KLRK1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-602639.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | KLRK1 | ||||||||||||||||||||||
Protein Name | killer cell lectin-like receptor subfamily K, member 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000446003 | ||||||||||||||||||||||
InnateDB Gene | IDBG-237489 (KLRK1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269PubMed:10426994, ECO:0000269PubMed:11224526, ECO:0000269PubMed:11777960, ECO:0000269PubMed:15240696, ECO:0000269PubMed:21898152, ECO:0000269PubMed:23298206}. | ||||||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:10426994, ECO:0000269PubMed:11015446, ECO:0000269PubMed:15294961}; Single- pass type II membrane protein {ECO:0000269PubMed:10426994, ECO:0000269PubMed:11015446, ECO:0000269PubMed:15294961}. Note=Colocalized with HCST on the cell surface. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269PubMed:10426993, ECO:0000269PubMed:15294961, ECO:0000269PubMed:16444266}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR001304
C-type lectin IPR002353 Type-2 ice-structuring protein IPR008646 Herpesvirus UL45-like IPR016187 C-type lectin fold |
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PFAM |
PF00059
PF05473 |
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PRINTS |
PR00356
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PIRSF | |||||||||||||||||||||||
SMART |
SM00034
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P26718 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P26718 | ||||||||||||||||||||||
TrEMBL | Q8WZ67 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 22914 | ||||||||||||||||||||||
UniGene | Hs.387787 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:18788 | ||||||||||||||||||||||
OMIM | 611817 | ||||||||||||||||||||||
CCDS | CCDS8623 | ||||||||||||||||||||||
HPRD | 17240 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC022075 AF260135 AF260136 AF439512 AF461811 AJ001687 AJ001688 AJ001689 AK292020 AK292059 BC039836 CH471094 X54870 | ||||||||||||||||||||||
GenPept | AAF86973 AAF86974 AAH39836 AAL35226 AAL65233 BAF84709 BAF84748 CAA04925 CAA38652 EAW96178 EAW96180 EAW96182 | ||||||||||||||||||||||