InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZIC1

Summary

InnateDB Protein

IDBP-60264.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZIC1

Protein Name

Zic family member 1

Synonyms

ZIC; ZNF201;

Species

Homo sapiens

Ensembl Protein

ENSP00000282928

InnateDB Gene

IDBG-60262 (ZIC1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}.

Disease Associations

Tissue Specificity

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. {ECO:0000269PubMed:8542595}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007389	pattern specification process
GO:0007417	central nervous system development
GO:0007420	brain development
GO:0007628	adult walking behavior
GO:0008589	regulation of smoothened signaling pathway
GO:0021510	spinal cord development
GO:0030154	cell differentiation
GO:0042307	positive regulation of protein import into nucleus
GO:0042472	inner ear morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated