Version 5.4
Homo sapiens Protein: APPL2
Summary
InnateDB Protein IDBP-602812.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APPL2
Protein Name adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000446917
InnateDB Gene IDBG-54652 (APPL2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0008283 cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010008 endosome membrane
GO:0016581 NuRD complex
GO:0031901 early endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
PFAM PF00169
PF00640
PF14719
PF08416
PRINTS
PIRSF
SMART SM00233
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEU8
PhosphoSite PhosphoSite-Q8NEU8
TrEMBL F8W124
UniProt Splice Variant
Entrez Gene 55198
UniGene
RefSeq NP_001238833
HUGO HGNC:18242
OMIM 606231
CCDS CCDS58276
HPRD 06945
IMGT
EMBL AC016257 AC078874 AK001521 AK296610 AK297100 AY113704 BC033731
GenPept AAH33731 AAM55530 BAH12397 BAH12496

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca