InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASP1

Summary

InnateDB Protein

IDBP-603023.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP1

Protein Name

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Synonyms

ICE; IL1BC; P45;

Species

Homo sapiens

Ensembl Protein

ENSP00000432340

InnateDB Gene

IDBG-69618 (CASP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	79 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type

PFAM

PF00619
PF00656

PRINTS

PR00376

PIRSF

PIRSF038001

SMART

SM00114
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References