Version 5.4
Homo sapiens Protein: SSX2IP
Summary
InnateDB Protein IDBP-603250.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSX2IP
Protein Name synovial sarcoma, X breakpoint 2 interacting protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000432261
InnateDB Gene IDBG-99995 (SSX2IP)
Protein Structure
UniProt Annotation
Function Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin. Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. {ECO:0000250, ECO:0000269PubMed:23816619}.
Subcellular Localization Cell junction, adherens junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Not found at cell-matrix AJs. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 31 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0051297 centrosome organization
Cellular Component
GO:0005634 nucleus
GO:0034451 centriolar satellite
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR021622 Afadin/alpha-actinin-binding
PFAM PF11559
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2D8
PhosphoSite PhosphoSite-Q9Y2D8
TrEMBL C9JIX7
UniProt Splice Variant
Entrez Gene 117178
UniGene Hs.627106
RefSeq
HUGO HGNC:16509
OMIM 608690
CCDS
HPRD 10566
IMGT
EMBL AB023140 AC114482 AK292475 AK294057 AL133046 AY367055 BC033637 BC064389 CH471097
GenPept AAH33637 AAH64389 AAQ72373 BAA76767 BAF85164 BAG57404 CAB61373 EAW73224 EAW73226 EAW73227 EAW73228

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca