Version 5.4
Homo sapiens Protein: CDCA3
Summary
InnateDB Protein IDBP-603282.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDCA3
Protein Name cell division cycle associated 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000442068
InnateDB Gene IDBG-15239 (CDCA3)
Protein Structure
UniProt Annotation
Function F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007067 mitotic nuclear division
GO:0008150 biological_process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99618
PhosphoSite PhosphoSite-Q99618
TrEMBL F5GX58
UniProt Splice Variant
Entrez Gene 83461
UniGene
RefSeq NP_112589
HUGO HGNC:14624
OMIM 607749
CCDS CCDS8565
HPRD 09670
IMGT
EMBL AK291421 BC002551 BC036512 BG354576 CH471116 U47924
GenPept AAB51327 AAH02551 AAH36512 BAF84110 EAW88728 EAW88729

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca