Version 5.4
Homo sapiens Protein: CST5
Summary
InnateDB Protein IDBP-60362.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST5
Protein Name cystatin D
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000307132
InnateDB Gene IDBG-60360 (CST5)
Protein Structure
UniProt Annotation
Function Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. {ECO:0000269PubMed:8083219}.
Subcellular Localization Secreted {ECO:0000269PubMed:20189825}.
Disease Associations
Tissue Specificity Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in parotid gland but not in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastric corpus, small intestine, liver, or gall bladder tissue. {ECO:0000269PubMed:20189825}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28325
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 1473
UniGene
RefSeq NP_001891
HUGO HGNC:2477
OMIM 123858
CCDS CCDS13162
HPRD 00463
IMGT
EMBL AL591074 BC062678 BC069514 X59964 X70377
GenPept AAH62678 AAH69514 CAA42590 CAA49838 CAI23644

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca