Version 5.4
Homo sapiens Protein: IL22
Summary
InnateDB Protein IDBP-603725.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL22
Protein Name interleukin 22
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000442424
InnateDB Gene IDBG-46046 (IL22)
Protein Structure
UniProt Annotation
Function Cytokine that contributes to the inflammatory response in vivo.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0045518 interleukin-22 receptor binding
Biological Process
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0007267 cell-cell signaling
GO:0045087 innate immune response (InnateDB)
GO:0051384 response to glucocorticoid
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR009079 Four-helical cytokine-like, core
IPR020444 Interleukin-24
IPR020453 Interleukin-22
PFAM PF14565
PRINTS PR01937
PR01936
PIRSF PIRSF037726
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GZX6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 50616
UniGene Hs.287369
RefSeq XP_005268986
HUGO HGNC:14900
OMIM 605330
CCDS CCDS8982
HPRD 05621
IMGT
EMBL AF279437 AF387519 AJ277247 AJ277248 AY358890 BC066263 BC067510 BC069112 BC069308 BC070261
GenPept AAG22064 AAH66263 AAH67510 AAH69112 AAH69308 AAH70261 AAK62468 AAQ89249 CAC06085 CAC19409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca