InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGNEF

Summary

InnateDB Protein

IDBP-603994.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGNEF

Protein Name

Rho-guanine nucleotide exchange factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000441436

InnateDB Gene

IDBG-231005 (RGNEF)

Protein Structure

UniProt Annotation

Function

Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with the microtubule radial and cortical systems. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding

Biological Process

GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00621
PF00169
PF00130
PF11929
PF12796

PRINTS

PIRSF

SMART

SM00325
SM00233
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8N1W1