InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDELR1

Summary

InnateDB Protein

IDBP-60401.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDELR1

Protein Name

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

Synonyms

ERD2; ERD2.1; HDEL; PM23;

Species

Homo sapiens

Ensembl Protein

ENSP00000329471

InnateDB Gene

IDBG-60399 (KDELR1)

Protein Structure

UniProt Annotation

Function

Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. {ECO:0000269PubMed:11703931}.

Subcellular Localization

Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269PubMed:14517323}; Multi-pass membrane protein {ECO:0000269PubMed:14517323}. Endoplasmic reticulum membrane {ECO:0000269PubMed:14517323}; Multi-pass membrane protein {ECO:0000269PubMed:14517323}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:14517323}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005046	KDEL sequence binding
GO:0046923	ER retention sequence binding

Biological Process

GO:0006621	protein retention in ER lumen
GO:0006886	intracellular protein transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030663	COPI-coated vesicle membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane