Version 5.4
Homo sapiens Protein: ASCL3
Summary
InnateDB Protein IDBP-604019.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASCL3
Protein Name achaete-scute complex homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000435770
InnateDB Gene IDBG-31041 (ASCL3)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. Inhibits myogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Widely expressed in fetal and adult tissues. {ECO:0000269PubMed:15475265}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NQ33
PhosphoSite PhosphoSite-Q9NQ33
TrEMBL
UniProt Splice Variant
Entrez Gene 56676
UniGene
RefSeq NP_065697
HUGO HGNC:740
OMIM 609154
CCDS CCDS7795
HPRD 18523
IMGT
EMBL AB046450 AJ400877
GenPept BAB83913 CAB92288

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca