Version 5.4
Homo sapiens Protein: MSI2
Summary
InnateDB Protein IDBP-60420.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSI2
Protein Name musashi homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000313616
InnateDB Gene IDBG-60416 (MSI2)
Protein Structure
UniProt Annotation
Function RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Note=Associated with polysomes. {ECO:0000250}.
Disease Associations Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).
Tissue Specificity Ubiquitous; detected at low levels. {ECO:0000269PubMed:12649177}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DH6
PhosphoSite PhosphoSite-Q96DH6
TrEMBL
UniProt Splice Variant
Entrez Gene 124540
UniGene Hs.741833
RefSeq NP_733839
HUGO HGNC:18585
OMIM 607897
CCDS CCDS11597
HPRD 07438
IMGT
EMBL AK093888 BC001526 BC017560
GenPept AAH01526 AAH17560 BAC04244

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca