InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FABP1

Summary

InnateDB Protein

IDBP-60426.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FABP1

Protein Name

fatty acid binding protein 1, liver

Synonyms

FABPL; L-FABP;

Species

Homo sapiens

Ensembl Protein

ENSP00000295834

InnateDB Gene

IDBG-60424 (FABP1)

Protein Structure

UniProt Annotation

Function

Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005324	long-chain fatty acid transporter activity
GO:0005504	fatty acid binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008144	drug binding
GO:0016209	antioxidant activity
GO:0032052	bile acid binding

Biological Process

GO:0006810	transport
GO:0008284	positive regulation of cell proliferation
GO:0015909	long-chain fatty acid transport
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0050892	intestinal absorption
GO:0051345	positive regulation of hydrolase activity
GO:0070301	cellular response to hydrogen peroxide
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0045179	apical cortex
GO:0070062	extracellular vesicular exosome