Homo sapiens Protein: CCS
Summary
InnateDB Protein IDBP-604274.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCS
Protein Name copper chaperone for superoxide dismutase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000436318
InnateDB Gene IDBG-59478 (CCS)
Protein Structure
UniProt Annotation
Function Delivers copper to copper zinc superoxide dismutase (SOD1).
Subcellular Localization Cytoplasm {ECO:0000269PubMed:9726962}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004784 superoxide dismutase activity
GO:0005375 copper ion transmembrane transporter activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015035 protein disulfide oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0015680 intracellular copper ion transport
GO:0019430 removal of superoxide radicals
GO:0030001 metal ion transport
GO:0035434 copper ion transmembrane transport
GO:0051353 positive regulation of oxidoreductase activity
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001424 Superoxide dismutase, copper/zinc binding domain
IPR006121 Heavy metal-associated domain, HMA
PFAM PF00080
PF00403
PRINTS PR00068
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14618
PhosphoSite PhosphoSite-O14618
TrEMBL J3KNF4
UniProt Splice Variant
Entrez Gene 9973
UniGene Hs.596654
RefSeq NP_005116
HUGO HGNC:1613
OMIM 603864
CCDS CCDS8146
HPRD 04841
IMGT
EMBL AF002210 AP001157 AY113179 BC105016 BC112055 CR541928
GenPept AAC51764 AAI05017 AAI12056 AAM50090 CAG46726