Version 5.4
Homo sapiens Protein: MAP1LC3B2
Summary
InnateDB Protein IDBP-604328.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP1LC3B2
Protein Name microtubule-associated protein 1 light chain 3 beta 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000450524
InnateDB Gene IDBG-59216 (MAP1LC3B2)
Protein Structure
UniProt Annotation
Function Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Endomembrane system {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}. Note=LC3-II binds to the autophagic membranes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006914 autophagy
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0012505 endomembrane system
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR004241 Autophagy protein Atg8 ubiquitin like
IPR007242 Ubiquitin-like protein Atg12
IPR029071 Ubiquitin-related domain
PFAM PF02991
PF04110
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NCE7
PhosphoSite PhosphoSite-A6NCE7
TrEMBL
UniProt Splice Variant
Entrez Gene 643246
UniGene
RefSeq NP_001078950
HUGO HGNC:34390
OMIM
CCDS CCDS41841
HPRD
IMGT
EMBL AC125603 CH471054 DN994744
GenPept EAW98085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca