InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CABP4

Summary

InnateDB Protein

IDBP-60466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CABP4

Protein Name

calcium binding protein 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000324960

InnateDB Gene

IDBG-60464 (CABP4)

Protein Structure

UniProt Annotation

Function

Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19338761}. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. {ECO:0000250}.

Disease Associations

Night blindness, congenital stationary, 2B (CSNB2B) [MIM:610427]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. {ECO:0000269PubMed:16960802}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in retina and in the inner hair cells (IHC) of the cochlea.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0007165	signal transduction
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0008594	photoreceptor cell morphogenesis
GO:0046549	retinal cone cell development
GO:0060040	retinal bipolar neuron differentiation