InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AIP

Summary

InnateDB Protein

IDBP-60517.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIP

Protein Name

aryl hydrocarbon receptor interacting protein

Synonyms

ARA9; FKBP16; FKBP37; SMTPHN; XAP-2; XAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000279146

InnateDB Gene

IDBG-60515 (AIP)

Protein Structure

UniProt Annotation

Function

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.Cellular negative regulator of the hepatitis B virus (HBV) X protein.

Subcellular Localization

Cytoplasm.

Disease Associations

Growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]: Pituitary adenomas include somatotropinoma and prolactinoma. {ECO:0000269PubMed:17244780, ECO:0000269PubMed:17299063, ECO:0000269PubMed:17360484, ECO:0000269PubMed:18410548}. Note=The disease is caused by mutations affecting the gene represented in this entry.ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]: A pituitary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. {ECO:0000269PubMed:17360484}. Note=The disease is caused by mutations affecting the gene represented in this entry.Prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]: Most common type of hormonally active pituitary adenoma. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0036004	GAF domain binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0006626	protein targeting to mitochondrion
GO:0006805	xenobiotic metabolic process
GO:0007165	signal transduction
GO:0010738	regulation of protein kinase A signaling
GO:0022417	protein maturation by protein folding
GO:0045087	innate immune response (InnateDB)
GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00254
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00170