InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFAP2A

Summary

InnateDB Protein

IDBP-60630.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFAP2A

Protein Name

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Synonyms

AP-2; AP-2alpha; AP2TF; BOFS; TFAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000316516

InnateDB Gene

IDBG-60624 (TFAP2A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	45 [view]
Protein-DNA	9 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001822	kidney development
GO:0003404	optic vesicle morphogenesis
GO:0003409	optic cup structural organization
GO:0006366	transcription from RNA polymerase II promoter
GO:0007605	sensory perception of sound
GO:0008285	negative regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010842	retina layer formation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0021559	trigeminal nerve development
GO:0021623	oculomotor nerve formation
GO:0030501	positive regulation of bone mineralization
GO:0035115	embryonic forelimb morphogenesis
GO:0042472	inner ear morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045595	regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0060021	palate development
GO:0060349	bone morphogenesis
GO:0061029	eyelid development in camera-type eye
GO:0070172	positive regulation of tooth mineralization
GO:0071281	cellular response to iron ion
GO:2000378	negative regulation of reactive oxygen species metabolic process