InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULT2B1

Summary

InnateDB Protein

IDBP-60655.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT2B1

Protein Name

sulfotransferase family, cytosolic, 2B, member 1

Synonyms

HSST2;

Species

Homo sapiens

Ensembl Protein

ENSP00000201586

InnateDB Gene

IDBG-60653 (SULT2B1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. {ECO:0000269PubMed:12145317, ECO:0000269PubMed:9799594}.

Subcellular Localization

Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus.

Disease Associations

Tissue Specificity

Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. {ECO:0000269PubMed:9799594}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004027	alcohol sulfotransferase activity
GO:0005515	protein binding
GO:0008146	sulfotransferase activity
GO:0050294	steroid sulfotransferase activity

Biological Process

GO:0000103	sulfate assimilation
GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process