InnateDB Protein
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IDBP-60657.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SULT2B1
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Protein Name
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sulfotransferase family, cytosolic, 2B, member 1
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Synonyms
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HSST2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000312880
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InnateDB Gene
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IDBG-60653 (SULT2B1)
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Protein Structure
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Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. {ECO:0000269PubMed:12145317, ECO:0000269PubMed:9799594}.
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Subcellular Localization |
Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. {ECO:0000269PubMed:9799594}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00685
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O00204
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PhosphoSite |
PhosphoSite-O00204
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6820
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UniGene |
Hs.369331
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RefSeq |
NP_004596
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HUGO |
HGNC:11459
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OMIM |
604125
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CCDS |
CCDS12724
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HPRD |
04991
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IMGT |
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EMBL |
AC008403
BC034694
U92314
U92315
U92316
U92317
U92318
U92319
U92320
U92321
U92322
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GenPept |
AAC78498
AAC78499
AAC78553
AAC78554
AAH34694
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