Version 5.4
Homo sapiens Protein: SPACA4
Summary
InnateDB Protein IDBP-60741.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPACA4
Protein Name sperm acrosome associated 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000312774
InnateDB Gene IDBG-60739 (SPACA4)
Protein Structure
UniProt Annotation
Function Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12788941}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:12788941}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269PubMed:12788941}. Note=Expressed in acrosomal matrix and outer and inner acrosomal membranes.
Disease Associations
Tissue Specificity Testis specific. Expressed in spermatozoa. {ECO:0000269PubMed:12788941}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001526 CD59 antigen
PFAM PF00021
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDM5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 171169
UniGene Hs.122599
RefSeq NP_598005
HUGO HGNC:16441
OMIM 609932
CCDS CCDS12725
HPRD 15421
IMGT
EMBL AF353721 AY358387 BC047334
GenPept AAH47334 AAL83950 AAQ88753

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca