Version 5.4
Homo sapiens Protein: APMAP
Summary
InnateDB Protein IDBP-60774.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APMAP
Protein Name chromosome 20 open reading frame 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000217456
InnateDB Gene IDBG-60770 (APMAP)
Protein Structure
UniProt Annotation
Function Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation. {ECO:0000269PubMed:18513186}.
Subcellular Localization Membrane {ECO:0000269PubMed:18513186}; Single-pass type II membrane protein {ECO:0000269PubMed:18513186}.
Disease Associations
Tissue Specificity Liver, glomerular and tubular structures of the kidney, endothelial cells, arterial wall and pancreatic islets of Langerhans (at protein level). Found ubiquitously in adult as well as in embryonic tissues. In adult tissue, the highest expression is found in the liver, placenta and heart. Found on the cell surface of monocytes. In embryonic tissue, the highest expression levels is found in the liver and the kidney. {ECO:0000269PubMed:18513186}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004064 arylesterase activity
GO:0016844 strictosidine synthase activity
Biological Process
GO:0008150 biological_process
GO:0009058 biosynthetic process
Cellular Component
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR013658 SMP-30/Gluconolactonase/LRE-like region
IPR018119 Strictosidine synthase, conserved region
PFAM PF08450
PF03088
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HDC9
PhosphoSite PhosphoSite-Q9HDC9
TrEMBL
UniProt Splice Variant
Entrez Gene 57136
UniGene Hs.472330
RefSeq NP_065392
HUGO HGNC:13238
OMIM 615884
CCDS CCDS13166
HPRD 09840
IMGT
EMBL AB033767 AK025834 AK026866 AK291129 AK301959 AL035661 AY359076 BC003501
GenPept AAH03501 AAQ89435 BAB11885 BAB15253 BAB15578 BAF83818 BAG63373 CAB75499

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca