InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDGFA

Summary

InnateDB Protein

IDBP-6080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDGFA

Protein Name

platelet-derived growth factor alpha polypeptide

Synonyms

PDGF-A; PDGF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000346508

InnateDB Gene

IDBG-6078 (PDGFA)

Protein Structure

UniProt Annotation

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted. Note=Released by platelets upon wounding.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001775	cell activation
GO:0001942	hair follicle development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002576	platelet degranulation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009611	response to wounding
GO:0009790	embryo development
GO:0009887	organ morphogenesis
GO:0010033	response to organic substance
GO:0010035	response to inorganic substance
GO:0010512	negative regulation of phosphatidylinositol biosynthetic process
GO:0010544	negative regulation of platelet activation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014910	regulation of smooth muscle cell migration
GO:0030031	cell projection assembly
GO:0030036	actin cytoskeleton organization
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0031954	positive regulation of protein autophosphorylation
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0032956	regulation of actin cytoskeleton organization
GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042060	wound healing
GO:0042493	response to drug
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043588	skin development
GO:0045087	innate immune response
GO:0045740	positive regulation of DNA replication
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048146	positive regulation of fibroblast proliferation
GO:0048286	lung alveolus development
GO:0048839	inner ear development
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050919	negative chemotaxis
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0060683	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005902	microvillus
GO:0009986	cell surface
GO:0016020	membrane
GO:0031093	platelet alpha granule lumen