InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEFA1B

Summary

InnateDB Protein

IDBP-6089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEFA1B

Protein Name

defensin, alpha 1B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000372136

InnateDB Gene

IDBG-402312 (DEFA1B)

Protein Structure

UniProt Annotation

Function

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. {ECO:0000269PubMed:15616305, ECO:0000269PubMed:17452329}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0002227	innate immune response in mucosa
GO:0006805	xenobiotic metabolic process
GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006955	immune response
GO:0009615	response to virus
GO:0019731	antibacterial humoral response
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0031640	killing of cells of other organism
GO:0042742	defense response to bacterium
GO:0045087	innate immune response
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus
GO:0051607	defense response to virus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix
GO:0035578	azurophil granule lumen
GO:0070062	extracellular vesicular exosome