InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCNT2

Summary

InnateDB Protein

IDBP-60912.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCNT2

Protein Name

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)

Synonyms

bA360O19.2; bA421M1.1; CCAT; CTRCT13; GCNT2C; GCNT5; IGNT; II; NACGT1; NAGCT1; ULG3;

Species

Homo sapiens

Ensembl Protein

ENSP00000314844

InnateDB Gene

IDBG-60908 (GCNT2)

Protein Structure

UniProt Annotation

Function

Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C.

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

In the adult, highly expressed in prostate and to a lesser extent in small intestine and colon. Barely detected in heart, brain, kidney and pancreas. No expression in placenta, lung, liver, skeletal muscle, spleen, thymus, testis, ovary and peripheral blood leukocytes. In fetus, highly expressed in brain and to a lesser extent in lung and kidney. Barely detected in liver. {ECO:0000269PubMed:12424189, ECO:0000269PubMed:9405606}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375	acetylglucosaminyltransferase activity