InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL27

Summary

InnateDB Protein

IDBP-60962.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL27

Protein Name

chemokine (C-C motif) ligand 27

Synonyms

ALP; CTACK; CTAK; ESKINE; ILC; PESKY; SCYA27;

Species

Homo sapiens

Ensembl Protein

ENSP00000259631

InnateDB Gene

IDBG-236604 (CCL27)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Testis, thymus, placenta, ovary and skin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007267	cell-cell signaling
GO:0060326	cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001811 Chemokine interleukin-8-like domain

PFAM

PF00048

PRINTS

PIRSF

SMART

SM00199

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y4X3

PhosphoSite

PhosphoSite-

TrEMBL

Q5VZ77

UniProt Splice Variant

Entrez Gene

10850

UniGene

Hs.648124

RefSeq

NP_006655

HUGO

HGNC:10626

OMIM

604833

CCDS

CCDS6569

HPRD

05321

IMGT

EMBL

AB010445 AF082393 AJ243542 BC148263 CH471071 EF064762

GenPept

AAD41238 AAI48264 ABK41945 BAA87046 CAB46983 EAW58421